Journal
BIOINFORMATICS
Volume 30, Issue 21, Pages 3131-3133Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btu425
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Funding
- Swiss National Science Foundation [31003A_141215]
- Macquarie University Research Excellence Scheme Postgraduate Scholarship
- Australian National eResearch Collaboration Tools and Resources project [RT016]
- Swiss National Science Foundation (SNF) [31003A_141215] Funding Source: Swiss National Science Foundation (SNF)
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Sequencing oligosaccharides by exoglycosidases, either sequentially or in an array format, is a powerful tool to unambiguously determine the structure of complex N- and O-link glycans. Here, we introduce GlycoDigest, a tool that simulates exoglycosidase digestion, based on controlled rules acquired from expert knowledge and experimental evidence available in GlycoBase. The tool allows the targeted design of glycosidase enzyme mixtures by allowing researchers to model the action of exoglycosidases, thereby validating and improving the efficiency and accuracy of glycan analysis.
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