Journal
CELL
Volume 103, Issue 3, Pages 481-490Publisher
CELL PRESS
DOI: 10.1016/S0092-8674(00)00139-2
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Funding
- NCI NIH HHS [R37-CA37395, CA 47632, P01 CA072006, CA72006, R37 CA037395-18, R01 CA047632-12, P01 CA072006-020003, R37 CA037395] Funding Source: Medline
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The matrix metalloproteinase MMP-9/gelatinase B is upregulated in angiogenic dysplasias and invasive cancers of the epidermis in a mouse model of multistage tumorigenesis elicited by HPV16 oncogenes. Transgenic mice lacking MMP-9 show reduced keratinocyte hyperproliferation at all neoplastic stages and a decreased incidence of invasive tumors. Yet those carcinomas that do arise in the absence of MMP-9 exhibit a greater loss of keratinocyte differentiation, indicative of a more aggressive and higher grade tumor. Notably, MMP-9 is predominantly expressed in neutrophils, macrophages, and mast cells, rather than in oncogene-positive neoplastic cells. Chimeric mice expressing MMP-9 only in cells of hematopoietic origin, produced by bone marrow transplantation, reconstitute the MMP-9-dependent contributions to squamous carcinogenesis. Thus, inflammatory cells can be coconspirators in carcinogenesis.
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