Journal
BIOINFORMATICS
Volume 29, Issue 15, Pages 1895-1897Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btt315
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Funding
- UQ Research Scholarship
- UQ International Research Tuition Award
- National Health & Medical Research Council Australia [631668]
- National Institutes of Health [RO-1 RR021692-01]
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At the heart of many modern biotechnological and therapeutic applications lies the need to target specific genomic loci with pinpoint accuracy. Although landmark experiments demonstrate technological maturity in manufacturing and delivering genetic material, the genomic sequence analysis to find suitable targets lags behind. We provide a computational aid for the sophisticated design of sequence-specific ligands and selection of appropriate targets, taking gene location and genomic architecture into account.
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