Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 25, Issue 11, Pages 548-555Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(00)01689-3
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The regulated alteration of chromatin structure, termed 'chromatin remodeling', can be accomplished by covalent modification of histones or by the action of ATP-dependent remodeling complexes. A variety of mechanisms can be used to remodel chromatin; some act locally on a single nucleosome and others act more broadly. It is critical to establish a direct connection between the remodeling events observed in vivo and the mechanistic capabilities of remodeling complexes in vitro.
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