Journal
BIOINFORMATICS
Volume 29, Issue 22, Pages 2931-2932Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btt501
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Transcription activator-like effector nucleases (TALENs) have become an accepted tool for targeted mutagenesis, but undesired off-targets remain an important issue. We present TALENoffer, a novel tool for the genome-wide prediction of TALEN off-targets. We show that TALENoffer successfully predicts known off-targets of engineered TALENs and yields a competitive runtime, scanning complete mammalian genomes within a few minutes.
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