Journal
BIOINFORMATICS
Volume 29, Issue 15, Pages 1913-1914Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btt298
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Funding
- FWO-Vlaanderen [G.0413.09]
- European Research Council [240 186]
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We present PIUS, a tool that identifies peptides from tandem mass spectrometry data by analyzing the six-frame translation of a complete genome. It differs from earlier studies that have performed such a genomic search in two ways: (i) it considers a larger search space and (ii) it is designed for natural peptide identification rather than proteomics. Differently from other peptidomics tools designed for genome-wide searches, PIUS does not limit the analysis to a set of sequences that match a list of de novo reconstructions.
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