Journal
BIOINFORMATICS
Volume 28, Issue 19, Pages 2407-2411Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/bts464
Keywords
-
Categories
Funding
- Intramural funds of the National Library of Medicine, National Institutes of Health, USA
Ask authors/readers for more resources
Gibberellic acids (GAs) are key plant hormones, regulating various aspects of growth and development, which have been at the center of the 'green revolution'. GRAS family proteins, the primary players in GA signaling pathways, remain poorly understood. Using sequence-profile searches, structural comparisons and phylogenetic analysis, we establish that the GRAS family first emerged in bacteria and belongs to the Rossmann fold methyltransferase superfamily. All bacterial and a subset of plant GRAS proteins are likely to function as small-molecule methylases. The remaining plant versions have lost one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. We predict that GRAS proteins might either modify or bind small molecules such as GAs or their derivatives.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available