Journal
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
Volume 94, Issue 6, Pages 625-628Publisher
ROYAL SOC TROPICAL MEDICINE
DOI: 10.1016/S0035-9203(00)90211-6
Keywords
malaria; ivermectin; Anopheles farauti; modelling; vector control; host management
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We, investigated mortality in Anopheles farauti mosquitoes, a major coastal malaria vector in the south-west Pacific, fed on a volunteer who had taken a 250 mug/kg dose of ivermectin. High mortality was recorded in mosquitoes feeding during the first week after treatment of the volunteer, for instance 100-80% failed to survive 3 days. A long-term residual effect of ivermectin in the blood was indicated by a small but significantly higher mortality in mosquitoes fed 6 weeks after ivermectin was taken. These effects were included in malaria transmission models that incorporated host choice and host-induced mortality parameters. For the zoophilic An. farauti, ivermectin treatment of animals resulted in a greater reduction in malaria than ivermectin treatment of humans alone, whereas for an anthropophilic vector, treatment of humans was more important. This suggests that ivermectin treatment of animals could have an important role in malaria control where An. farauti is the vector. Improvement in the health of humans and domestic animals through control of parasitic worms and mites might encourage community participation in strategies involving ivermectin.
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