Journal
VETERINARY PATHOLOGY
Volume 37, Issue 6, Pages 677-680Publisher
AMER COLL VET PATHOLOGIST
DOI: 10.1354/vp.37-6-677
Keywords
anterior uveitis; eye; immunohistochemistry; llamas; malignant teratoid medulloepithelioma; medulloepithelioma; retinal detachment
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Amyloid precursor protein (APP) immunocytochemistry was used to study axonal and neuronal changes in guinea pig brains exposed to tunicamycin. Substantial axonal injury was found in ischemic-hypoxic foci and more generally, but this injury was not readily appreciable in conventionally stained sections. Neuronal perikaryal APP expression was also widely distributed, possibly as an acute phase response to this neurotoxin.
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