4.6 Review

Hijacking of apoptotic pathways by bacterial pathogens

Journal

MICROBES AND INFECTION
Volume 2, Issue 14, Pages 1705-1719

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/S1286-4579(00)01326-5

Keywords

Salmonella; Mycobacteria; apoptosis; Shigella; Chlamydia; Coxiella; Trypanosoma; parasites; Bordetella; Legionella; Yersinia

Funding

  1. NIAID NIH HHS [R29AI38410, R01 AI43965] Funding Source: Medline

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Increasing evidence indicates that apoptosis of the host cell may constitute a defense mechanism to confine the infection by bacterial pathogens. Certain pathogens have developed elegant mechanisms to modulate the fate of the host cell, which include induction or blockage of apoptosis. These studies will promote our understanding of the pathogenesis of infectious diseases and aid the development of means for therapeutic intervention. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

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