Journal
BIOINFORMATICS
Volume 28, Issue 7, Pages 1017-1020Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/bts048
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Funding
- Etat de Vaud
- Association Francaise contre les Myopathies
- European program Crescendo
- Swiss National Science Foundation [31003A_133011/1]
- Swiss Institute of Bioinformatics
- Swiss National Science Foundation (SNF) [31003A_133011] Funding Source: Swiss National Science Foundation (SNF)
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Motivation: Most anatomical ontologies are species-specific, whereas a framework for comparative studies is needed. We describe the vertebrate Homologous Organs Groups ontology, vHOG, used to compare expression patterns between species. Results: vHOG is a multispecies anatomical ontology for the vertebrate lineage. It is based on the HOGs used in the Bgee database of gene expression evolution. vHOG version 1.4 includes 1184 terms, follows OBO principles and is based on the Common Anatomy Reference Ontology (CARO). vHOG only describes structures with historical homology relations between model vertebrate species. The mapping to species-specific anatomical ontologies is provided as a separate file, so that no homology hypothesis is stated within the ontology itself. Each mapping has been manually reviewed, and we provide support codes and references when available.
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