Journal
BIOINFORMATICS
Volume 28, Issue 6, Pages 884-885Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/bts052
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Funding
- LMUexcellent guest professorship
- Deutsche Forschungsgemeinschaft [SFB646, TR5, FOR1068]
- NIM
- European Molecular Biology Organization (EMBO)
- European Research Council
- LMUinnovativ project Bioimaging Network (BIN)
- Jung-Stiftung
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Standard transcriptomics measures total cellular RNA levels. Our understanding of gene regulation would be greatly improved if we could measure RNA synthesis and decay rates on a genome-wide level. To that end, the Dynamic Transcriptome Analysis (DTA) method has been developed. DTA combines metabolic RNA labeling with standard transcriptomics to measure RNA synthesis and decay rates in a precise and non-perturbing manner. Here, we present the open source R/Bioconductor software package DTA. It implements all required bioinformatics steps that allow the accurate absolute quantification and comparison of RNA turnover.
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