Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 16, Issue 3, Pages 317-321Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0924-8579(00)00258-2
Keywords
anti fungal compounds; investigational azoles; investigational polyenes; antifungal targets
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Invasive fungal infections will continue to cause major complications in immunocompromized patients. At the moment, the expansion of antifungal drug research has occurred because there is a critical need for new antifungal agents to treat these life-threatening invasive fungal infections. Thr overview of the development of antifungal therapy which is provided here demonstrates the increased interest in this very special area of infectious diseases. Although we now have some newer and less toxic antifungal agents that are currently available for clinical use, their clinical efficacy in some invasive fungal infections, such as aspergillosis and fusariosis, is not very good. Intense efforts in antifungal drug discovery are urgently needed to develop more promising and effective antifungal agents for use in the clinical arena. (C) 2000 Published by Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.
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