ProfileChaser: searching microarray repositories based on genome-wide patterns of differential expression

We introduce ProfileChaser, a web server that allows for querying the Gene Expression Omnibus based on genomewide patterns of differential expression. Using a novel, content-based approach, ProfileChaser retrieves expression profiles that match the differentially regulated transcriptional programs in a user-supplied experiment. This analysis identifies statistical links to similar expression experiments from the vast array of publicly available data on diseases, drugs, phenotypes and other experimental conditions.