Journal
BIOINFORMATICS
Volume 28, Issue 4, Pages 581-583Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btr704
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Funding
- National Institutes of Health, National Library of Medicine
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CLARE is a computational method designed to reveal sequence encryption of tissue- specific regulatory elements. Starting with a set of regulatory elements known to be active in a particular tissue/process, it learns the sequence code of the input set and builds a predictive model from features specific to those elements. The resulting model can then be applied to user-supplied genomic regions to identify novel candidate regulatory elements. CLARE's model also provides a detailed analysis of transcription factors that most likely bind to the elements, making it an invaluable tool for understanding mechanisms of tissue- specific gene regulation.
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