Journal
BIOINFORMATICS
Volume 27, Issue 7, Pages 1036-1038Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btr052
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Funding
- National Institutes of Health [HHSN261200800001E, CA109872, CA149147, NS029525, GM085665]
- National Institutes of Health, National Institute on Aging
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Differential dependency network (DDN) is a caBIG(R) (cancer Biomedical Informatics Grid) analytical tool for detecting and visualizing statistically significant topological changes in transcriptional networks representing two biological conditions. Developed under caBIG(R)'s In Silico Research Centers of Excellence (ISRCE) Program, DDN enables differential network analysis and provides an alternative way for defining network biomarkers predictive of phenotypes. DDN also serves as a useful systems biology tool for users across biomedical research communities to infer how genetic, epigenetic or environment variables may affect biological networks and clinical phenotypes. Besides the standalone Java application, we have also developed a Cytoscape plug-in, CytoDDN, to integrate network analysis and visualization seamlessly.
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