Journal
BIOINFORMATICS
Volume 27, Issue 9, Pages 1322-1323Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btr119
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Funding
- Swedish Research Council [VR-NT 2009-5072, VR-M 2007-3065]
- SSF (the Foundation for Strategic Research)
- EU [LSHG-CT-2004-512092, FP7-HEALTH-F4-2007-201924]
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State-of-the-art methods for topology of alpha-helical membrane proteins are based on the use of time-consuming multiple sequence alignments obtained from PSI-BLAST or other sources. Here, we examine if it is possible to use the consensus of topology prediction methods that are based on single sequences to obtain a similar accuracy as the more accurate multiple sequence-based methods. Here, we show that TOPCONS-single performs better than any of the other topology prediction methods tested here, but similar to 6% worse than the best method that is utilizing multiple sequence alignments.
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