Journal
BIOINFORMATICS
Volume 27, Issue 15, Pages 2159-2160Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btr325
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SEAL is a scalable tool for short read pair mapping and duplicate removal. It computes mappings that are consistent with those produced by BWA and removes duplicates according to the same criteria employed by Picard MarkDuplicates. On a 16-node Hadoop cluster, it is capable of processing about 13GB per hour in map+rmdup mode, while reaching a throughput of 19GB per hour in mapping-only mode.
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