Journal
BIOINFORMATICS
Volume 28, Issue 4, Pages 453-456Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btr693
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Funding
- Wellcome Trust [83701/Z/07/Z]
- Singapore National Research Foundation [NRF-G-CRP-2007-04-082]
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microRibonucleic acid (miRNAs) are small regulatory molecules that act by mRNA degradation or via translational repression. Although many miRNAs are ubiquitously expressed, a small subset have differential expression patterns that may give rise to tissue- specific complexes. Motivation: This work studies gene targeting patterns amongst miRNAs with differential expression profiles, and links this to control and regulation of protein complexes. Results: We find that, when a pair of miRNAs are not expressed in the same tissues, there is a higher tendency for them to target the direct partners of the same hub proteins. At the same time, they also avoid targeting the same set of hub-spokes. Moreover, the complexes corresponding to these hub-spokes tend to be specific and nonoverlapping. This suggests that the effect of miRNAs on the formation of complexes is specific.
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