Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 64, Issue 11, Pages 2508-2511Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.64.2508
Keywords
enterohemorrhagic Escherichia coli (EHEC) O157 : H7; virulence factors; gene expression; quorum-sensing system; auoinducer
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Enterohemorrhagic Escherichia call (EHEC) O157:H7 causes serious diarrhea and hemolytic uremic syndrome in humans, The expressions of EspD and intimin by O157:H7 have now been shown to be downregulated by medium conditioned by O157:H7 grown at stationary phase. Preparation of conditioned medium showing the effect on the amount of EspD was not dependent on temperature or growth medium, but was dependent on growth phase. Inhibition of EspD and intimin expression was also induced by medium conditioned by E. coli K-12 strains and homoserine lactone, a signal molecule of the quorum-sensing system in Gram-negative bacteria, These results suggest the possibility that the quorum-sensing system mediated by self-produced extracellular factors plays an important role in control of colonization of EHEC O157:H7.
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