Journal
BIOINFORMATICS
Volume 27, Issue 2, Pages 275-276Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btq632
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Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior [CAPES-Fiocruz 30/2006]
- Programa de Desenvolvimento Tecnologico em Insumos para Saude (PDTIS-Fiocruz)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro
- National Institutes of Health [NIH 5R01MH067880, P41 RR011823]
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We present an approach to statistically pinpoint differentially expressed proteins that have quantitation values near the quantitation threshold and are not identified in all replicates (marginal cases). Our method uses a Bayesian strategy to combine parametric statistics with an empirical distribution built from the reproducibility quality of the technical replicates.
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