Journal
BIOINFORMATICS
Volume 26, Issue 9, Pages 1269-1270Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btq125
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Motivation: Linkage disequilibrium (LD) differences between populations can potentially result in failure to replicate primary signals of trait association in independent genome-wide association studies (GWAS). However, such inter-population LD differences can be leveraged to narrow the search for common causal variants responsible for the association signals observed. The ability to assess and quantify LD variations among populations is thus expected to contribute to both replication and. ne-mapping stages of GWAS.
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