Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 25, Issue 11, Pages 561-566Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(00)01669-8
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Translational termination has been a largely ignored aspect of protein synthesis for many years, However, the recent identification of new release-factor genes, the mapping of release-factor functional sites and in vitro reconstitution experiments have provided a deeper understanding of the termination mechanism. In addition, protein-protein interactions among release factors and with other proteins have been revealed. The three-dimensional structures of a prokaryotic ribosome recycling factor and eukaryotic release factor 1 (eRF1) mimic the shape of transfer RNA, indicating that they bind to the same ribosomal site, Post-termination events in bacteria have been clarified, linking termination, ribosomal recycling and translation initiation.
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