Journal
BIOINFORMATICS
Volume 26, Issue 9, Pages 1273-1275Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btq109
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Funding
- National Natural Science Foundation of China (NSFC) [30873159]
- MOE
- Science Planning Program of Fujian Province [2009J1010]
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The tissue-specific genes are a group of genes whose function and expression are preferred in one or several tissues/cell types. Identification of these genes helps better understanding of tissue-gene relationship, etiology and discovery of novel tissue-specific drug targets. In this study, a statistical method is introduced to detect tissue-specific genes from more than 123 125 gene expression profiles over 107 human tissues, 67 mouse tissues and 30 rat tissues. As a result, a novel subject-specialized repository, namely the tissue-specific genes database (TiSGeD), is developed to represent the analyzed results. Auxiliary information of tissue-specific genes was also collected from biomedical literatures.
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