4.2 Article

Nonenzymatic template-directed synthesis of RNA from monomers

Journal

MOLECULAR BIOLOGY
Volume 34, Issue 6, Pages 781-789

Publisher

CONSULTANTS BUREAU
DOI: 10.1023/A:1026663422976

Keywords

prebiotic RNA synthesis; activated mononucleotides; peptide nucleic acid; hexitol nucleic acid; altritol nucleic acid; wobble pairing; enantiomeric cross-inhibition

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Reviewed are the latest achievements in studying the information transfer mechanisms and the evolutionary significance of prebiotic RNA synthesis, the double helix structures most preferred in this respect, and the possible reasons for the prevalence of particular enantiomeric forms of nucleotides in template-directed synthesis.

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