Journal
BIOINFORMATICS
Volume 26, Issue 18, Pages 2328-2333Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btq417
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Funding
- Excellence Cluster CardioPulmonary System (ECCPS)
- International Max Planck Research School for Heart and Lung Research (IMPRS-HLR)
- Max Planck Society
- DFG [Br1416]
- EU
- Kerckhoff-Foundation
- Excellence Initiative 'Cardiopulmonary System'
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Motivation: Due to the development of high-throughput technologies such as microarrays,it has become possible to determine genome-wide expression changes in a single experiment. Although much attention has been paid to identify differentially expressed genes, the functions of tens of thousands of genes in different species still remain unknown. Results: C-It is a knowledge database that has its focus on 'uncharacterized genes'. C-It contains expression profiles of various tissues from human, mouse, rat, chicken and zebrafish. By applying our previously introduced algorithm DGSA (Database-Dependent Gene Selection and Analysis), it is possible to screen for uncharacterized, tissue-enriched genes in the species mentioned above. C-It is designed to include further expression studies, which might provide more comprehensive coverage of gene expression patterns and tissue-enriched splicing isoforms. We propose that C-It will be an excellent starting point to study uncharacterized genes. Availability: C-It is freely available online without registration at
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