4.7 Article

CGHnormaliter: a Bioconductor package for normalization of array CGH data with many CNAs

Journal

BIOINFORMATICS
Volume 26, Issue 10, Pages 1366-1367

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btq155

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Funding

  1. Netherlands Genomics Initiative
  2. Netherlands Bioinformatics Centre

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CGHnormaliter is a package for normalization of array comparative genomic hybridization (aCGH) data. It uses an iterative procedure that effectively eliminates the influence of imbalanced copy numbers. This leads to a more reliable assessment of copy number alterations (CNAs). CGHnormaliter is integrated in the Bioconductor environment allowing a smooth link to visualization tools and further data analysis.

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