Journal
BIOMATERIALS
Volume 21, Issue 21, Pages 2163-2169Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0142-9612(00)00137-X
Keywords
poly(2-hydroxyethyl methacrylate); porous hydrogel; phase separation; porosity
Funding
- NIGMS NIH HHS [5T32GMO8362-10] Funding Source: Medline
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Macroporous poly(2-hydroxyethyl methacrylate) (p(HEMA)) hydrogels were prepared in the presence of a 0.3-0.7 M NaCl solution. The pore morphology of the p(HEMA) hydrogels was dependent on the concentration of NaCl for a constant monomer solution to aqueous solution ratio. Swelling studies showed an increase in equilibrium water content and hydrogel porosity as the NaCl concentration in the polymerization medium increased from 0 to 0.7 M. The equilibrium water content, however, decreased as the NaCl concentration in the swelling medium increased. The frozen water content increased and non-frozen water decreased with an increase in the NaCl concentration in the polymerization medium. Mechanical testing indicated that the elastic modulus of the hydrogels was not affected by the increased porosity until the pores became interconnected. These data suggest that the addition of NaCl to the polymerization medium results in a multi-phase separation during fabrication that produces macroporous hydrogels of controlled morphology. (C) 2000 Elsevier Science Ltd. All rights reserved.
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