Journal
BIOINFORMATICS
Volume 25, Issue 9, Pages 1211-1213Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btp124
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Funding
- Polytechnic University of Marche
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The correct post-transcriptional RNA processing is finely regulated by RNA-binding proteins. Unfortunately, there is little experimental information on target RNA sequences of RNA-binding proteins and moreover such experimentally derived target sequences are annotated in a compact form by the score matrices that overestimate the number of possible recognized sequences. We carried out an exhaustive hand curated literature search to create a database, SpliceAid, collecting all the experimentally assessed target RNA sequences that are bound by splicing proteins in humans. We built a web resource, database driven, to easy query SpliceAid and give back the results by an accurate and dynamic graphic representation.
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