Journal
BIOLOGICAL CHEMISTRY
Volume 381, Issue 11, Pages 1133-1138Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2000.139
Keywords
cell cycle; heat shock protein; nuclear localization; stress protein
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The co-chaperone murine stress-inducible protein 1 (mSTI1), a Hsp70/Hsp90 organizing protein (Hop) homolog, functions as a physical link between Hsp70 and Hsp90 by mediating the formation of the mSTI1/ Hsp70/Hsp90 chaperone heterocomplex. We show here that mSTI1 is an in vitro substrate of cell cycle kinases. Casein kinase II (CKII) phosphorylates mSTI1 at S-189, and cdc2 kinase (p34(cdc2)) at T-198, substantiating a predicted CKII-p34(cdc2)-NLS (CcN) motif. The possible implications of this phosphorylation as a cell cycle checkpoint are discussed.
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