Journal
TRENDS IN GENETICS
Volume 16, Issue 11, Pages 512-517Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0168-9525(00)02125-9
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Funding
- NIGMS NIH HHS [GM56615] Funding Source: Medline
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Virus mutators (mutant alleles that confer a higher mutant-frequency phenotype than that of the wild type) and antimutators (mutant alleles that confer a lower mutant-frequency phenotype) were discovered in bacteriophage T4 over three decades ago, but there is only limited detailed knowledge about such genetic variants in viruses that infect humans and threaten public health. The creation of mutators and antimutators during the course of viral infection (particularly in the case of RNA viruses) could play a pivotal role in virus evolution, pathogenesis and emergence, and could also frustrate antiviral therapy.
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