Journal
BIOINFORMATICS
Volume 25, Issue 18, Pages 2418-2424Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btp424
Keywords
-
Categories
Funding
- Convocatoria de ayudas para proyectos I+D+I para grupos de investigacion emergentes 2007 Generalitat Valenciana' [GV/2007/025]
- 'BANCAJA-UMH' [IP/UR/01]
- 'Conselleria de Empresa, Universidad y Ciencia de la Generalitat Valenciana' [GV07/017]
- EC [01663]
- EMBO Long Term Fellowship
- Fundacao para Ciencia e Tecnologia [SFRH/BDP/41583/2007]
- [505520]
Ask authors/readers for more resources
Motivation: Most of the structures and functions of proteome globular domains are yet unknown. We can use high-resolution structures from different modular domains in combination with automatic protein design algorithms to predict genome-wide potential interactions of a protein. ADAN database and related web tools are online resources for the predictive analysis of ligand domain complexes. ADAN database is a collection of different modular protein domains (SH2, SH3, PDZ, WW, etc.). It contains 3505 entries with extensive structural and functional information available, manually integrated, curated and annotated with cross-references to other databases, biochemical and thermodynamical data, simplified coordinate files, sequence files and alignments. Prediadan, a subset of ADAN database, offers position-specific scoring matrices for protein-protein interactions, calculated by FoldX, and predictions of optimum ligands and putative binding partners. Users can also scan a query sequence against selected matrices, or improve a ligand-domain interaction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available