Journal
EMBO JOURNAL
Volume 19, Issue 21, Pages 5772-5781Publisher
WILEY
DOI: 10.1093/emboj/19.21.5772
Keywords
apoptosis; cell proliferation; HLH inhibitor; Id2; mammary gland
Categories
Funding
- NCIPC CDC HHS [U17 CE002005] Funding Source: Medline
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Id proteins are thought to be negative regulators of cell differentiation and positive regulators of cell proliferation. Mammary glands of ITd2(-/-) female mice reveal severely impaired lobulo-alveolar development during pregnancy. Id2(-/-) mammary epithelia show no precocious maturation, but instead exhibit intrinsic defects in both cell proliferation and cell survival, implying that the role of Id2 in pregnant mammary epithelia is mainly stimulation of cell proliferation and support of cell viability. Expression studies of genes required for mammary gland development suggest Id2 to be a downstream or parallel factor of these genes. A decrease in the DNA binding activity of Stat5 was also observed in Id2(-/-) mammary glands at 7 days post-coitus. Our results indicate an indispensable role of Id2 in pregnant mammary glands.
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