Journal
MOLECULAR MEDICINE TODAY
Volume 6, Issue 11, Pages 433-440Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1357-4310(00)01810-4
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Gene therapy vectors based on the adeno-associated virus (AAV) are being developed for a widening variety of therapeutic applications. Enthusiasm for AAV is due, not only to the relative safety of these vectors, but also to advances in understanding of the unique biology of this virus. This review examines a number of long-standing concerns regarding the utility of AAV for gene transfer in light of many new insights into the biology, immunology and production of AAV.
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