Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 111, Issue 2, Pages 647-649Publisher
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.1365-2141.2000.02355.x
Keywords
myeloproliferative disorder; translocation; FGFR1 gene; chromosome 8; chromosome 19
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Translocations affecting the chromosomal locus 8p12 are hallmarks of an atypical stem cell myeloproliferative disorder. These events disrupt the fibroblast growth factor receptor 1 (FGFR1) gene and fuse the FGFR1 C-terminus catalytic domain with unrelated proteins. Here, we report on the characterization of the 19q13.3 locus as the fifth FGFR1 chromosomal partner.
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