4.7 Article

Model aggregation: a building-block approach to creating large macromolecular regulatory networks

Journal

BIOINFORMATICS
Volume 25, Issue 24, Pages 3289-3295

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btp581

Keywords

-

Funding

  1. National Institutes of Health [R01-GM07898901]
  2. Technology Centers for Networks and Pathways [U54RR022232]

Ask authors/readers for more resources

Motivation: Models of regulatory networks become more difficult to construct and understand as they grow in size and complexity. Modelers naturally build large models from smaller components that each represent subsets of reactions within the larger network. To assist modelers in this process, we present model aggregation, which defines models in terms of components that are designed for the purpose of being combined. Results: We have implemented a model editor that incorporates model aggregation, and we suggest supporting extensions to the Systems Biology Markup Language (SBML) Level 3. We illustrate aggregation with a model of the eukaryotic cell cycle 'engine' created from smaller pieces.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available