Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 111, Issue 1-2, Pages 215-223Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(00)00357-X
Keywords
CD4; CD49d; cerebrospinal fluid; cytokines; multiple sclerosis; relapse
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In the animal model of multiple sclerosis, experimental autoimmune encephalomyelitis, encephalitogenic T cells differ from the non-encephalitogenic ones in their expression of CD49d. The disease-inducing CD49d(high) and not the CD49d(low) cells enter the brain parenchyma. In this context, we characterized CD4(+)(CD45RO(+))CD49d(high) cells in relapsing-remitting multiple sclerosis (RR-MS) patients. These cells, showing characteristics of activated cells able to produce pro-inflammatory cytokines, were found to be increased in peripheral blood during relapses and present in high numbers in cerebrospinal fluid. These results suggest that the CD4(+)CD45RO(+)CD49d(high) subpopulation in RR-MS patients includes autoreactive cells and may be target for immunotherapy. (C) 2000 Elsevier Science BN. All rights reserved.
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