Journal
JOURNAL OF BIOTECHNOLOGY
Volume 201, Issue -, Pages 28-42Publisher
ELSEVIER
DOI: 10.1016/j.jbiotec.2014.08.021
Keywords
Microalgae; Light conversion efficiency; Truncated antenna mutants; Strain engineering; Calvin cycle
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Funding
- Fonds National de la Recherche Scientifique [FRFC 2.4567.11]
- European Union [245070 KBBE SUNBIOPATH]
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Microalgae represent promising organisms for the sustainable production of commodities, chemicals or fuels. Future use of such systems, however, requires increased productivity of microalgal mass cultures in order to reach an economic viability for microalgae-based production schemes. The efficiency of sunlight-to-biomass conversion that can be observed in bulk cultures is generally far lower (35-80%) than the theoretical maximum, because energy losses occur at multiple steps during the light-driven conversion of carbon dioxide to organic carbon. The light-harvesting system is a major source of energy losses and thus a prime target for strain engineering. Truncation of the light-harvesting antenna in the algal model organism Chlamydomonas reinhardtii was shown to be an effective way of increasing culture productivity at least under saturating light conditions. Furthermore engineering of the Calvin-Benson cycle or the creation of photorespiratory bypasses in A. thaliana proved to be successful in terms of achieving higher biomass productivities. An efficient generation of novel microalgal strains with improved sunlight conversion efficiencies by targeted engineering in the future will require an expanded molecular toolkit. In the meantime random mutagenesis coupled to high-throughput screening for desired phenotypes can be used to provide engineered microalgae. (C) 2014 Elsevier B.V. All rights reserved.
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