Journal
BIOINFORMATICS
Volume 24, Issue 24, Pages 2938-2939Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btn564
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Funding
- NHLBI's Framingham Heart Study [N01-HC-25195]
- NHLBI CARe (Candidate Gene Association Resource) [N01-HC-65226]
- Intramural training program of the NHLBI
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The interpretation of genome-wide association results is confounded by linkage disequilibrium between nearby alleles. We have developed a flexible bioinformatics query tool for single-nucleotide polymorphisms (SNPs) to identify and to annotate nearby SNPs in linkage disequilibrium (proxies) based on HapMap. By offering functionality to generate graphical plots for these data, the SNAP server will facilitate interpretation and comparison of genome-wide association study results, and the design of fine-mapping experiments (by delineating genomic regions harboring associated variants and their proxies).
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