Journal
ACCOUNTS OF CHEMICAL RESEARCH
Volume 33, Issue 11, Pages 805-812Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ar000063m
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- NIGMS NIH HHS [GM-24893] Funding Source: Medline
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The oxidative folding of proteins is reviewed and illustrated with bovine pancreatic ribonuclease A (RNase A). The mutual effects of conformational folding and disulfide bond regeneration are emphasized, particularly the locking in of native disulfide bonds by stable tertiary structure in disulfide intermediates. Two types of structured metastable disulfide species are discerned, depending on the relative protection of their disulfide bonds and thiol groups. Four generic pathways for oxidative folding are identified and characterized.
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