Journal
BIOINFORMATICS
Volume 24, Issue 14, Pages 1639-1640Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btn251
Keywords
-
Categories
Funding
- NIAID NIH HHS [P01 AI61734] Funding Source: Medline
Ask authors/readers for more resources
We present a suite of on-line tools to design candidate vaccine proteins, and to assess antigen potential, using coverage of k-mers (as proxies for potential T-cell epitopes) as a metric. The vaccine design tool uses the recently published mosaic method to generate protein sequences optimized for coverage of high-frequency k-mers; the coverage-assessment tools facilitate coverage comparisons for any potential antigens. To demonstrate these tools, we designed mosaic protein sets for B-clade HIV-1 Gag, Pol and Nef, and compared them to antigens used in a recent human vaccine trial.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available