Journal
BIOINFORMATICS
Volume 24, Issue 24, Pages 2928-2929Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btn550
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Funding
- Swedish Natural Sciences Research Council
- Wallenberg Consortium North
- Knut & Alice Wallenberg Foundation
- SSF (the Foundation for Strategic Research)
- EU 6th Framework Program [LSHG-CT-2004-512092]
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SPOCTOPUS is a method for combined prediction of signal peptides and membrane protein topology, suitable for genome-scale studies. Its objective is to minimize false predictions of transmembrane regions as signal peptides and vice versa. We provide a description of the SPOCTOPUS algorithm together with a performance evaluation where SPOCTOPUS compares favorably with state-of-the-art methods for signal peptide and topology predictions.
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