Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 82, Issue 1-4, Pages 123-125Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0162-0134(00)00141-0
Keywords
axial thiolate ligand; hydrocarbon oxidation; iron porphyrin; active intermediates; cytochrome P450
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In order to examine the reactivity of active intermediate derived form iron porphyrins, competitive oxidations of alkane and alkene were carried out. It has been proposed that the first step of alkane hydroxylation is Il atom abstraction and that of alkene is one-electron transfer. Therefore, it is expected that alkene-alkane competitive oxidation can be used as a probe for discrimination of differences in chemical properties among active species. Cytochrome P450 and SR complex, which is a stable thiolate-ligated iron porphyrin, mediated the oxidation of alkane much more preferentially than iron porphyrin coordinated by imidazole or chloride. These results indicate that thiolate coordination alters the reactivity of the two-electron-oxidize intermediate in a manner that is much more favorable to alkane hydroxylation than the case of chloride or imidazole coordination. (C) 2000 Elsevier Science B.V. All rights reserved.
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