Journal
BIOINFORMATICS
Volume 24, Issue 23, Pages 2786-2787Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btn522
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Funding
- National Institutes of Health [GM72861]
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This article introduces a new forward population genetic simulation program that can efficiently generate samples from populations with complex demographic histories under various models of natural selection. The program (SFS_CODE) is highly flexible, allowing the user to simulate realistic genomic regions with several loci evolving according to a variety of mutation models (from simple to context-dependent), and allows for insertions and deletions. Each locus can be annotated as either coding or non-coding, sex-linked or autosomal, selected or neutral, and have an arbitrary linkage structure (from completely linked to independent).
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