Journal
JOURNAL OF CLINICAL PSYCHIATRY
Volume 61, Issue 11, Pages 858-862Publisher
PHYSICIANS POSTGRADUATE PRESS
DOI: 10.4088/JCP.v61n1108
Keywords
-
Categories
Funding
- NCRR NIH HHS [5M01-RR00056] Funding Source: Medline
- NIMH NIH HHS [MH01414] Funding Source: Medline
Ask authors/readers for more resources
Background: Antidepressant-induced periodic limb movement disorder (PLMD) may limit the tolerability of some antidepressant medications and interfere with treatment response. Given the role of dopamine in PLMD and the effects of bupropion sustained-release (SR) on central dopaminergic function, we hypothesized that bupropion SR would not be associated with antidepressant-induced PLMD. Method: In an expanded case-series design, we compared the effects of bupropion SR, after about 10 weeks of treatment, on measures of PLMD, depression, and sleep in 5 depressed (Research Diagnostic Criteria) patients who also met criteria for having pretreatment PLMD. Depression was measured using the Beck Depression Inventory and the Hamilton Rating Scale for Depression. Patients were considered to have PLMD if polysomnographic recordings showed > 5 periodic limb movements/hour of sleep that were associated with arousals from sleep. Results: Bupropion SR treatment was associated with a reduction in measures of PLMD and an improvement in depression. Conclusion: These results show that bupropion SR is not associated with antidepressant-induced PLMD, Rather, bupropion SR treatment reduces objective measures of PLMD in depressed patients with the disorder.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available