Journal
BIOINFORMATICS
Volume 24, Issue 20, Pages 2416-2417Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btn439
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Funding
- High-Tech Research and Development Program of China [2006AA02Z329]
- National Natural Science Foundation of China [60573093]
- National Basic Research Program of China [2006CB910700, 2004CB720103, 2004CB518606, 2003CB715901]
- Funding of Chinese Academy of Sciences [KSCX2-YW-R-112]
- Shanghai Pujiang Program [06PJ14073]
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Investigation of transcription factors (TFs) and their downstream regulated genes (targets) is a significant issue in post-genome era, which can provide a brand new vision for some vital biological process. However, information of TFs and their targets in mammalian is far from sufficient. Here, we developed an integrated TF platform (ITFP), which included abundant TFs and their targets of mammalian. In current release, ITFP includes 4105 putative TFs and 69496 potential TF-target pairs for human, 3134 putative TFs and 37040 potential TF-target pairs for mouse, and 1114 putative TFs and 18055 potential TF-target pairs for rat. In short, ITFP will serve as an important resource for the research community of transcription and provide strong support for regulatory network study.
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