Journal
NATURE NEUROSCIENCE
Volume 3, Issue 11, Pages 1121-1127Publisher
NATURE AMERICA INC
DOI: 10.1038/80639
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Funding
- NEI NIH HHS [R01EY11498, P30EY05722] Funding Source: Medline
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In addition to rod photoreceptor loss, many mutations in rod photoreceptor-specific genes cause degeneration of other neuronal types. Identifying mechanisms of cell-cell interactions initiated by rod-specific mutations and affecting other retinal cells is important for understanding the pathogenesis and progression of retinal degeneration. Here we show in animals with rod and cone degeneration due to mutations in the genes encoding rhodopsin and cGMP phosphodiesterase beta -subunit (PDE-beta) respectively, that rod bipolar cells received ectopic synapses from cones in the absence of rods. Thus, synaptic plasticity links certain rod-specific mutations to retina-wide structural alterations that involve different types of neurons.
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