Journal
MECHANISMS OF DEVELOPMENT
Volume 98, Issue 1-2, Pages 95-98Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(00)00432-9
Keywords
embryonic; lung; Notch; Delta; jagged; radical fringe; lunatic fringe; endoderm
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Factors controlling the differentiation of the multipotent embryonic lung endoderm and mesoderm are poorly understood. Recent evidence that Delta-like 1 (Dll1) and other genes in the Notch/Delta signaling pathway are expressed in the embryonic mouse lung suggests that this pathway is important for cell fate decisions and/or the differentiation of lung cell types. Here, we report the localization of transcripts of several genes encoding members of the Notch/Delta pathway in the early mouse lung. Most genes are expressed in specific populations and so may contribute to cell diversification. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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