Journal
BIOINFORMATICS
Volume 25, Issue 1, Pages 123-125Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btn576
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Funding
- The National Natural Science Foundation of China [10225210, 30770499, 10721403]
- National Basic Research Program of China [2003CB715905]
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We report a new and simple method, TriTISA, for accurate prediction of translation initiation site (TIS) of microbial genomes. TriTISA classifies all candidate TISs into three categories based on evolutionary properties, and characterizes them in terms of Markov models. Then, it employs a Bayesian methodology for the selection of true TIS with a non-supervised, iterative procedure. Assessment on experimentally verified TIS data shows that TriTISA is overall better than all other methods of the state-of-the-art for microbial genome TIS prediction. In particular, TriTISA is shown to have a robust accuracy independent of the quality of initial annotation.
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