Journal
TRENDS IN CELL BIOLOGY
Volume 10, Issue 11, Pages 466-473Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0962-8924(00)01841-9
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Funding
- NCI NIH HHS [R33 CA094304] Funding Source: Medline
- NIGMS NIH HHS [R01 GM027800-27] Funding Source: Medline
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Morphologic polarity is necessary for the motility of mammalian cells. In leukocytes responding to a chemoattractant, this Polarity is regulated by activities of small Rho guanosine triphosphatases (Rho GTPases) and the phosphoinositide 3-kinases (PI3Ks). Moreover, in neutrophils, lipid products of PI3Ks appear to regulate activation of Rho GTPases, are required fur cell motility and accumulate asymmetrically to the plasma membrame at the leading edge of polarized cells. By spatially regulating Rho GTPases and organizing the leading edge of the cell, PI3Ks and their lipid products could play pivotal roles not only in establishing leukocyte polarity but also as compass molecules that tell the cell where to crawl.
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